Endocrine Abstracts

Introduction: Pregnancy under the age of 19 is considered high-risk1; and a pregnancy with diabetes at this age further increases that risk2,3. With the correct advice and counselling, these risks can be greatly reduced. Here we describe a strategy to raise awareness by addressing this as part of regular clinic visits.Method: Prior knowledge of potential complications of pregnancy was assessed as part of a clinical consultation. Evi...

Neurotensin is widely expressed in the brain and gastrointestinal tract. Centrally, neurotensin acts as a neuropeptide to suppress appetite, induce hypothermia and modulate analgesia. Peripherally, neurotensin inhibits gastric emptying and is reported to aid lipid absorption. There is also evidence that neurotensin can influence glucose homeostasis, though this role is contentious. We have found that neurotensin acutely improves insulin release and glucose tolerance in mice, a...

Introduction: In patients with neuroendocrine tumours (NETs) somatostatin analogues are used to control symptoms in patients with functioning tumours and as antiproliferative agents in those with non-functioning tumours. During COVID-19, the ‘Sandostatin Your Choice’ service was terminated by Novartis, removing home care nurses from administering the analogue in patients’ homes. The first generic version of depot octreotide was Olatuton® produced by Teva, a...

Introduction: Association between lymphoma and pituitary dysfunction is well documented, though most commonly through mechanism of infiltrative pituitary metastasis, or primary lymphoma of the pituitary, rather than autoimmune lymphocytic hypophysitis. Here we present a highly unusual case whereby investigation into the cause of Diabetes Insipidus with radiological features of lymphocytic hypophysitis, led to diagnosis and cure of Diffuse Large B-cell lymphoma (DLBCL). Diabete...

Case history: A 53-year-old male with melanoma who had a previous surgical excision of his skin lesion in December 2018 was being treated with adjuvant pembrolizumab. In June 2019 his treatment changed to combination immune checkpoint inhibitor therapy (ICPi) with ipilimumab and nivolumab due to radiological recurrence.Investigations: There were no pre-ICPi endocrine investigations available. In July 2019, thyroid function tests (TFTs) showed thyroid-sti...

Objective: To review impact of childhood cancer treatment on endocrine, gonadal and thyroid function.Methods: Retrospective review of electronic records of 79 females, 90 males over 6 months of clinic visits from a Late Effects of childhood cancer clinic. Age at diagnosis: 8.5 years (range 5 months–9 years); time from treatment 23.5 years (range 10–40). Diagnoses: ALL, AML, Hodgkin’s lymphoma, Non-Hodgkin’s lymphoma, sarcomas, Wilms, ...

Introduction: Hospital schools can provide structure and learning for young people throughout a planned admission. With guidance, teachers can be a vital resource for assessing the numeracy and literacy skills essential in the management of diabetes. They can also provide a source of valuable pastoral and organisational expertise useful to the diabetes multidisciplinary team (MDT).Method: School teaching, pastoral and planning skills can be used to help ...

Introduction: Insulinoma visualization is the most difficult stage of diagnosis of this disease. Currently, in most cases the contrast-enhanced multislice computer tomography of abdomen and retroperitoneal space (CE-MSCT) is the method of choice in topical diagnosis of insulinoma. This method is associated with radiation exposure and administration of contrast agents, so it is invasive. Thus, an alternative highly informative and safe method for initial topical diagnosis of in...

Few studies have evaluated bone histomorphometry in type 2 diabetic patients (DM2) and none has established if the disease control plays a role on bone morphology and bone marrow adipocytes. The aim of this study is to present preliminary data on bone microstructure, bone formation rate and bone marrow adipocytes in premenopausal women with DM2 with different levels of glucose control. Bone biopsy, followed by tetracycline labelling, was obtained for analysis of static and dyn...

Thyroid storm (TS) is a rare and life threatening condition that requires a prompt recognition and treatment. The clinical features may overlap with other acute medical conditions. Currently both Akamizu Criteria (JTA) and Burch and Wartofsky Scale (BW) are helpful diagnostics tools.Objective: To evaluate TS patients according to currently available criteria and to identify the clinical features and outcomes.Methods: A single cente...